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The U.S. Department of Energy’s Oak Ridge Office of Environmental Management uses three prime contractors to conduct its major cleanup projects at the site. These companies include URS|CH2M Oak Ridge LLC (UCOR), Wastren Advantage Inc. (WAI), and Isotek Systems LLC.

UCOR is the Department of Energy's primary cleanup contractor for the DOE Oak Ridge Reservation, primarily focused on cleanup of East Tennessee Technology Park (the former Oak Ridge K-25 Site). UCOR is also engaged in cleanup and waste management activities at the Oak Ridge National Laboratory and the Y-12 National Security Complex. UCOR is a partnership of URS and CH2M HILL, and its team subcontractor Restoration Services, Inc. is one of Oak Ridge's most successful woman-owned small businesses. 

WAI is a Small Business Administration Certified 8(a) small disadvantaged business headquartered in Piketon, Ohio. In Oak Ridge, WAI operates the Transuranic Waste Processing Center for the Environmental Management program. The company is responsible for all aspects of operations at the facility, including the processing, packaging, and shipping of all remote-handled and contact-handled transuranic waste. Additionally, WAI processes, treats, and prepares low-level and mixed low-level radioactive waste, and hazardous or industrial waste, for disposal.

Isotek is a wholly-owned subsidiary of EnergySolutions. The company’s principal mission in Oak Ridge is the disposition of the Department’s inventory of Uranium-233 from Building 3019, the world’s oldest operating nuclear facility, which is located at the Oak Ridge National Laboratory.