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Dr. Peter B. Lyons was confirmed by the Senate as the Assistant Secretary for Nuclear Energy on April 14, 2011. Dr. Lyons was appointed to his previous role as Principal Deputy Assistant Secretary of the Office of Nuclear Energy in September, 2009. As Assistant Secretary, Dr. Lyons is responsible for all programs and activities of the Office of Nuclear Energy.

Mr. Miotla currently serves as Chief Operating Officer and acting Principal Deputy Assistant Secretary for the Office of Nuclear Energy. Mr. Miotla shares responsibilities with the Assistant Secretary for all research, development, demonstration, and deployment activities of the Office. Prior to his current position, Mr. Miotla was Deputy Director for Nuclear Facility Operations. In that position he was responsible for the Idaho National Laboratory site programs.

Mr. Johnson serves as the Deputy Assistant Secretary for Science and Technology Innovation in the Office of Nuclear Energy (NE). He has held numerous senior management positions within NE including: Chief Operating Officer; Acting Director for the Office of Nuclear Energy, Science and Technology; Deputy Director for Technology; Associate Director for Advanced Nuclear Research; and Associate Director for Technology and International Cooperation.

As the Acting Deputy Assistant Secretary for Nuclear Facility Operations, Ms. Tracey Bishop is responsible for the management of the Office of Nuclear Energy’s infrastructure, safety and security programs, including NE’s field operations at the Idaho National Laboratory and the Nuclear Energy Oak Ridge Site Office. 

Dr. Regalbuto is currently the Deputy Assistant Secretary for Fuel Cycle Technologies with the Department of Energy’s Office of Nuclear Energy, whose mission promotes nuclear power as a resource capable of meeting the Nation's energy, environmental and national security needs. She previously served as a Senior Program Manager with the Office of Waste Processing with the Department of Energy’s Office of Environmental Management, supporting technical risk reduction and uncertainty in the Department’s clean-up programs. From 2003 to 2008, Dr.

Mr. McGinnis is responsible for the Department of Energy's international civilian nuclear energy activities, including international nuclear energy research, development and demonstration cooperation, international framework and partnership development, international nuclear energy policy, and other international civilian nuclear energy-related activities carried out by the Department of Energy's Office of Nuclear Energy. As part of these responsibilities, Mr.

Dr. John E. Kelly was appointed Deputy Assistant Secretary for Nuclear Reactor Technologies in the Office of Nuclear Energy in October 2010. His office is responsible for civilian nuclear reactor research and development portfolio, which includes DOE’s programs on Small Modular Reactors, Light-water reactor (LWR) sustainability, and Generation IV reactors. His office also is responsible for the design, development, and production of radioisotope power systems principally for NASA missions. In the international arena, Dr. Kelly chairs the Generation IV International Forum.