Ames Laboratory has limited activities involving nanomaterials. Potential hazards associated with nanomaterials work are addressed through the Laboratory’s Integrated Safety Management System (ISMS) and specifically the Readiness Review process. Readiness Review provides the identification and evaluation of potential hazards and establishes effective control mechanisms to ensure protection of the employee and the environment. To date, hazards associated with projects involving nanomaterials have been determined to be amenable to conventional controls such as ventilation and use of personal protective equipment. The Laboratory recognizes that nanotechnology is an emerging field and that many of the associated ES&H concerns related to work with these materials are still being investigated. Ames Laboratory safety professionals monitor professional sources of information to identify new control strategies associated with nanomaterials research.