This guide assists local, state, tribal and federal agencies in conducting tabletops, drills and exercises for transportation emergencies. Tabletops, drills and exercises facilitate a learning environment where response agencies can come together to understand and talk through an integrated response for a radiological transportation emergency. The accident scenarios provided with this manual may be modified to demonstrate some or all aspects of a response by one or more agencies. The scenarios include: spent nuclear fuel; low-specific activity material; transuranic waste; soil moisture/density gauge; radiopharmaceuticals; and a radiography device. Each scenario provides basic instructions on all aspects of event preparation, and describes how to use the other materials in the package. Used properly, these scenarios should enhance emergency preparedness by enabling communities to practice and demonstrate their ability to respond to a transportation emergency.