Located at the Savannah River Site in Aiken, South Carolina, the Attenuation-Based Remedies in the Subsurface Applied Field Research Initiative (ABRS AFRI) was established to develop the tools, approaches and technologies that will be required to address the technical challenges associated characterization, remediation and long-term monitoring of recalcitrant compounds in the subsurface at Department of Energy (DOE) Environmental Management (EM) sites. The ABRS AFRI site provides a unique setting for researchers in both applied and basic science fields. A wealth of subsurface data is available to support research activities and remedial decision making. Led by the Savannah River National Laboratory (SRNL), the initiative is a collaborative effort that leverages DOE investments in applied research and basic science and the work of the site contractors to address the complex challenges of subsurface metal and radionuclide contamination, as well as recalcitrant organics. The mission of the Attenuation Based Remedies in the Subsurface Applied Field Research Initiative is to seek holistic solutions to DOE’s groundwater contamination problems that consider not only the technical aspects of a waste site, but regulator, stakeholder, and end-user concerns as well.